At the beginning of the creation and development of history of science，those who changed from physics to history of science have made great contributions. The young physicist Price shifted his interests to history of science in the middle of the last century，but the experience and thoughts in physics have never been away from his study，but to help him to develop many perspectives，such as the quantitative study of history of science， the concept of“big science”and the thought of “cross-fertilization”. This story not only reflects the obsession for physics of the historian of science Derek Price，but also provides another way to realize the integration of subjects.