The method of Michelson interference in the optical part of college physics is applied to the measurement of electric field -strain effect. The experimental principle of electric field - strain effect measurement using Michelson interference is analyzed. The electric field-strain effect of LiNbO3 crystal is measured experimentally and the factors affecting the measurement accuracy is analyzed. The results have shown that the method of Michelson interference can be used to measure electric field-strain effect very well.