The construction of medical physics course at Shandong University is introduced in this paper. Many teaching reforms are taken in medical physics in recent years. Student-centered teaching philosophy runs throng the teaching process. Medical physics teaching resources are put on MOOC platform and opened to everyone. New form textbook is studied and will be published，in which a perfect teaching textbook system is established. In addition， the blended teaching mode based on SPOC online course is used and flipped class mode is tried in the face-to-face class. Furthermore，a variety of effective teaching methods are employed in classes. Research results have showed that the multi-dimensional teaching reforms have greatly promoted the level of medical physics course construction and improved the quality and effect of teaching at the same time.