Relying on the construction of provincial first-class online and offline mixed curriculum of atomic physics, with the help of Erya general education online course platform of our university, in this paper the exploration and practice of the mixed teaching mode of atomic physics are actively carried out by using the learning wisdom teaching software. Through the process of online resource construction, teaching mode exploration and teaching mode practice, the teaching concept has been changed and the one body, two cores and four combinations mixed teaching mode have been innovatively constructed, which provide a certain reference for the reform of online and offline mixed teaching mode in local colleges and universities.